You are here: Home > Multi-organ Injury, Multi-organ Dysfunction Syndrome, Multi-organ Failure : A New View of Whole Body Radiation Effects		Planning Guidance for Response to a Nuclear Detonation, 1/2009 (Homeland Security Council) Key Response Planning Factors for the Aftermath of Nuclear Terrorism, 8/2009 (Lawrence Livermore National Laboratory) Population Monitoring in Radiation Emergencies: A Guide for State and Local Public Health Planners, 8/2007 (HHS/CDC)    New Users: Where Do I Start? What's New on REMM Patient Management Algorithms Print Algorithms & Tables Isotopes of Interest Countermeasures Decontamination Procedures Dose Estimator for Exposure Manage ARS Subsyndromes Multi-organ Dysfunction Syndrome Hematopoietic Subsyndrome Cutaneous Radiation Syndrome Time/Dose Effects in ARS Time Phases of ARS Strategic National Stockpile Animations, Illustrations, Photos Dictionary Emergency Contacts Download REMM (6/2009) Download Mobile REMM (6/2009)    AFRRI AHRQ CDC CRCPD DHS DOE EPA FDA HHS   HPS IAEA ICRP NCRP NRC OSHA REAC/TS RITN WHO
	Multi-organ Injury, Multi-organ Dysfunction Syndrome, Multi-organ Failure: A New View of Whole Body Radiation Effects Acute Radiation Syndrome: the traditional view of radiation injury Features 4 predominanant acute subsyndromes Traditionally thought to represent the most prominent effects of significant doses of whole body radiation These subsyndromes form the basis of the European METREPOL concept of diagnosis and triage of radiation injury.1 (See Manage Subsyndromes of Acute Radiation Syndrome). The METREPOL system is being extensively revised, as new concepts of radiation injury become better understood, as noted below. MOI, MODS, MOF: the new view of radiation injury European researchers have recently proposed a new concept of radiation pathophysiology which is a clinical continuum of Multi-organ Injury (MOI) Multi-organ Dysfunction Syndrome (MODS) Multi-organ Failure (MOF), which is irreversible Features of this new concept include Systemic effects which are not limited to the 4 organ subsyndromes noted above Marked involvement of lung, kidney, liver and other organs in addition to those in the ARS subsyndromes, seen particularly at the higher doses Inflammation as a prominent feature of early radiation injury, although the role of anti-inflammatory treatment is unknown and could be detrimental (i.e., use of corticosteroids in the face of immunosuppression) Key descriptions and references about MOI, MOF, MODS are in Fliedner TM, Dorr HD, Meineke V. Multi-organ involvement as a pathogenetic principle of the radiation syndromes: a study involving 110 case histories document in SEARCH and classified as the bases of haematopoietic indicators of effect. BJR Suppl. 2005;27:1-8. [PubMed Citation] Bertho JM, Roy L, Souidi M, Benderitter M, Gueguen Y, Lataillade JJ, Prat M, Fagot T, De Revel T, Gourmelon P, New biological indicators to evaluate and monitor radiation-induced damage: an accident case report. Radiat Res. 2008 May;169(5):543-50. [PubMed Citation] References: Fliedner TM, Friesecke I, Beyrer K. Medical Management of Radiation Accidents: Manual on the Acute Radiation Syndrome. (METREPOL) (PDF - 970 KB) (originally published by Oxford: British Institute of Radiology; 2001) Compendium to the main METREPOL document (PDF - 580 KB) Radiation-Induced Multi-Organ Involvement and Failure: A Challenge for Pathogenetic, Diagnostic and Therapeutic Approaches and Research, BJR Suppl. 2005;27. top of page

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