REMM Bibliography -
Medical Management of Radiation Injury (Exposure)



General information

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Acute Radiation Syndrome (ARS)

  • Complete blood count (CBC) as predictor of hematopoietic ARS severity
  • Other guidance
  • Insights from research
  • Issues related to neutron and mixed neutron/gamma radiation
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    Pregnancy and fetal issues in radiation incidents

    See REMM At-Risk / Special Needs Populations:

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    Infants' and children's issues in mass casualty incidents including radiation incidents

    Policy issues

    Resources

    Techniques for pediatric incident mass casualty triage

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    Hematopoietic stem cell transplantation

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    Gastrointestinal Subsyndrome of ARS

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    Use of myeloid cytokines

    Use in adults

    Use in non-human primates

    Research on using cytokines in non-standard dosing schedules

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    Use of antiemetics


    See Guidelines for Use of Antiemetics


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    Management of febrile neutropenia

    Introduction

    • In clinical oncology, diagnosis and treatment of fever and neutropenia is a common problem. Many clinical practice guidelines and evidence reviews have been published, with periodic updates as understanding of the pathophysiology improves, and new drugs and regimens are introduced.
    • During a mass casualty radiation emergency, diagnosis and treatment of fever and neutropenia will surely occur among those who receive a high enough dose from exposure to whole- or partial-body radiation.
    • REMM clinical guidance focuses mainly on mass casualty radiation emergencies. In the absence of formal, prospective research on optimal guidelines for diagnosis and treatment of fever and neutropenia during large, mass casualty radiation emergencies, REMM citations and links on this topic are largely based on peer-reviewed publications in clinical oncology and expert opinion. These links and citations serve as background information only. No uniformly accepted clinical guidance exists for optimal regimens during large mass casualty radiation emergencies, especially when adequate resources may be inadequate at least initially, and crisis standards of care may be implemented.
    • See REMM’s Fever and Neutropenia sections in the Template for Hospital Orders in adults and children. Treatment options are offered by REMM and RITN experts as guidance, but no specific regimen is officially endorsed. Every patient should be managed individually, with the resources and information available at the time the patient is seen.

    See REMM information about Acute Radiation Syndrome, Exposure Algorithm, Dose Estimation, Time-Dose Effects, Crisis Standards of Care

    Children


    Adults

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    Platelet transfusion

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    Use of blood products

    See: Use of blood products

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    Radiation skin effects

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